Now is the time to
Step up
for immunisation...
not step away
Global Summit: Health & Prosperity through Immunization
Join us in Brussels on June 25, 2025 for Gavi's next five-year strategic period
Countdown to Replenishment
Dear Donor Letter Campaign: Open Letter Toolkit 2025
200+ civil society organizations worldwide have signed an open letter urging donor governments to fully fund Gavi’s replenishment at the Global Summit: Health & Prosperity through Immunisation on June 25th in Brussels. This unprecedented coalition represents grassroots organizations, international NGOs, health advocates, and community groups demanding prioritization of child immunization.
Over the next 5 years, full funding for Gavi, the Vaccine Alliance can save 8+ million lives, immunize 500 million children, and generate over $100 billion in economic benefits. Each $1 of investment in immunization brings $21 of wider economic returns, making this one of the most cost-effective health interventions available.
Your organization’s voice could be instrumental in amplifying this collective call for donor governments to make ambitious financial commitments to protect children from preventable diseases.
Some of the leaders we are targeting include:
Ursula von der Leyen, European Commission
Gavi, the Vaccine Alliance:
Dear Heads of State and Donors of Gavi, the Vaccine Alliance,
As representatives of civil society organisations working on the frontlines of global immunisation efforts, we write with urgency ahead of Gavi, the Vaccine Alliance’s's Global Summit: Health and Prosperity through Immunisation. In this critical moment, when official development assistance faces unprecedented cuts, your full support of Gavi's 6.0 investment case—$11.9 billion, including $9 billion in new pledges—has never been more vital. This is not merely a funding request; it is a moral imperative to protect the most vulnerable children worldwide.
The progress we've collectively achieved in reducing child mortality stands as one of humanity's greatest accomplishments, yet the harsh reality persists: 4.9 million children still die annually from preventable diseases. Even more troubling, 14.5 million zero-dose children remain completely unreached by basic immunisation services, with over half living in fragile and conflict-affected settings where vaccines represent their best hope for survival. In this crucial moment, stepping away from immunisation would represent an unconscionable retreat from our shared commitment to these children.
Those of us working directly with communities witness both the miraculous impact of vaccines and the devastating consequences of their absence. When a child dies from measles, pneumonia, or diarrhoea, we understand intimately that these are not merely statistics—they are preventable tragedies. Gavi's support has proven transformative in strengthening health systems, empowering communities, and saving lives in contexts where few other interventions succeed.
Gavi's unique model continues to drive sustainable impact through country ownership and innovative partnerships. This approach is projected to catalyze an impressive $4 billion in country commitments for the upcoming strategic period, demonstrating recipient countries' growing investment in their own immunization programs. The successful graduation of 19 countries from Gavi support further validates this sustainability-focused model. Equally important is Gavi's strategic engagement with the private sector, which has been instrumental in driving efficiency, innovation, and value across vaccine markets. This has yielded benefits not just for Gavi recipient countries but has contributed to creating a strong global vaccine ecosystem that has benefited all countries.
Gavi 6.0 represents the Alliance's most ambitious and comprehensive strategy yet, with plans to vaccinate at least 500 million children, save 8-9 million lives, protect 50 million children against malaria, generate $100 billion in economic benefits for implementing countries, and reduce prices across 50% of Gavi's vaccine portfolio. In the next strategic period, Gavi will accelerate its work to reduce the number of ‘zero-dose’ and under-immunised children, strengthen community engagement and build on 25 years of shaping global vaccine markets. This will contribute to achieving both equity of access as well as a thriving vaccine ecosystem with which lifesaving vaccines are developed and deployed. Most recently, Gavi’s continues to illustrate its innovative and transformative model through supporting local vaccine manufacturing through groundbreaking initiatives like the African Vaccine Manufacturing Accelerator (AVMA).
The COVID-19 pandemic, proliferating humanitarian crises, and intensifying climate-related disasters have demonstrated unequivocally that global health security is indivisible—our health systems are only as strong as their weakest links. Your investment in Gavi is an investment in global resilience and security that directly benefits us all, both home and abroad.
The economic case is irrefutable: every dollar invested in immunisation generates $54 in broader societal benefits. Yet beyond these compelling numbers lies a profound truth: we possess the knowledge and tools to prevent millions of childhood deaths. The only question is whether we possess the will, and the leadership needed to deploy them. We urge you to make pledges to fully fund Gavi's investment case, support its focus on equity and reaching zero-dose children and to maintain your unwavering political commitment to global immunization as a cornerstone priority.
The next five years will determine whether we achieve the Sustainable Development Goals and the Immunization Agenda 2030. With Gavi fully funded, we can make unprecedented progress in ending vaccine-preventable deaths and fulfilling every child's fundamental right to health.
In this moment of global uncertainty, your leadership is indispensable. When future generations look back on this pivotal time, they will judge us by our actions, not our words. This is not a time to retreat from our commitments—it is the moment to strengthen them. Because saving these children's lives is not merely aspirational; it is humanly possible. Now is Time to Step Up; Not Step Away!
With urgency and hope,
The Gavi CSO Constituency
25 Years of Impact: Our Journey Continues
Since its inception 25 years ago, Gavi has helped to protect over 1 billion children, helping to halve child mortality in our implementing countries. As we mark our jubilee year, we also look forward to our most ambitious period ever:
Protecting Our World.
Preventing and responding to outbreaks of diseases that can so easily spread across borders.
Expanding Our Reach.
Protecting more people, against more diseases, faster than ever before.
Strengthening Communities.
Building resilience to fragility, climate change and other threats through improved health systems.
- Reach 500 million children, saving 8–9 million lives from 2026–2030, including 50 million children with malaria vaccines and at least 120 million girls with the HPV vaccine, which protects against cervical cancer.
- Reach more zero-dose children, with a goal to halve their number by 2030.
- Deepen partnerships with countries, which will fund more than 40% of the costs of the vaccines themselves.
- Make our largest-ever investment in health security, investing in programmes and stockpiles capable of responding to over 150 outbreaks.
- Make over half the vaccines in our portfolio able to help countries adapt to the climate change and antimicrobial resistance.
- Help countries improve their health systems to facilitate over 1.4 billion individual contacts - enabling more integrated primary health care and Universal Health Coverage.
- Over the past 25 years, Gavi has not only protected a whole generation of children from disease, it has also helped to protect our entire world by preventing and responding to outbreaks of diseases that can easily spread across borders.
- In the next five years, its role in the frontline of the world's health security system will be even more important. Through routine immunisation,
- Gavi helps to prevent outbreak-prone diseases such as measles.
- Gavi is helping the world prepare for future pandemics by creating the US$ 2.5 billion Day Zero Financing Facility and making available up to US$ 1 billion for the African Vaccine Manufacturing Accelerator (AVMA).
- Thanks to Gavi's market-shaping efforts, production of cholera vaccines has increased 18-fold in the last decade.
- By maintaining global stockpiles for other outbreak-prone diseases such as Ebola, yellow fever, meningitis and in future Mpox, Gavi is fighting on the front line to help keep deadly diseases at bay.
- As a co-lead of COVAX, Gavi helped deliver 2 billion COVID-19 vaccine doses to 146 countries during the pandemic.
- Supporting Gavi is not just good for human health, it is also good for economic development and over 25 years Gavi has helped economies to grow and become self-sufficient. In the next five years, a fully funded Gavi will play an even more important role as countries face new and serious challenges.
- With every dollar invested in Gavi generating 54 dollars/euros in wider economic benefits, Gavi's work will generate US$ 100 billion of economic benefits for Gavi-supported countries from 2026–2030.
- Half of Gavi's vaccine portfolio will help countries adapt and respond to climate change and reduce the use of antibiotics.
- Sharpening our focus on gender-related barriers will help us reach more zero-dose children and facilitate hundreds of millions of contacts between families and health services through routine vaccination.
- Over the next five years, countries will make their largest ever investment in immunisation, paying almost 50% of the costs of their routine vaccines and placing them in the driving seat of their immunisation strategies.
We are inviting signatories from CSOs, the highest official in your organization (CEO, President, Chair etc). to sign-on this call to action that will also be used to send targeted letters to donors.